The Evidence Based and Clinical Benefits of Natural Progesterone | Miscarriage | Preterm Birth

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  SOLO2016  RATIONALE FOR THE USE OF  PROGESTERONE IN PREGNANCY G.C. DI RENZO, MD, PhD, FRCOG(hon) FACOG (hon) FICOG (hon) Dept of Obstetrics and Gynecology & Centre of Perinatal and Reproductive Medicine, University of Perugia, Perugia Italy  Utilisation in therapy amenorrhoeadysfunctional uterine bleeding premenstrual syndrome endometrial hyperplasia contraceptive (alone or in combination with an oestrogen) hormonal support in luteal phase deficiency, both in AR and in pregnancy maintenancerecurrent miscarriagepreterm labour  (Di Renzo et al., 2001).  The multiple physiological roles of progesterone, together with its pharmacokinetics and pharmacodynamics, have been extensively studied throughout the years. Since 1935 progesterone has been synthesised and later on become available on the market; during the following years its use become common in clinical practice. Hovewer, the use of progesterone in the pathophysiology of pregnancy remains arguable for various reasons.  Reasons few randomised controlled trials, with different dosages and populations. another important issue concerning progesterone is the route in which the hormone is administered. As a consequence, there have been restrictions in the therapeutic application of progesterone in the prevention and treatment of threatened miscarriage, recurrent miscarriage and preterm birth.
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